| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Enhanced effects of osteoclastogenesis inhibition by curcumin-delivering heparin nanoparticles |
| 초록 |
We developed curcumin-delivering heparin-based nanoparticles and evaluated the inhibition effects of osteoclastogenesis by curcumin-delivering heparin nanoparticles (Cur-HD NPs). Cur-HD NPs were dispersed well in aqueous solution to form self-assembled nanoparticles and showed sustained release of curcumin. In vitro studies, HD NPs facilitated intracellular delivery of curcumin into macrophages and osteoclasts, and thus, Cur-HD NPs effectively inhibited osteoclastogenesis in a dose-dependent manner by suppressing tartrate-resistant acid phosphatase (TRAP) activity and TRAP-positive multinucleated cells as well as by reducing the expression of osteoclast marker genes [i.e., TRAP and nuclear factor of activated T cells cytoplasmic 1 (NFATc1)]. Furthermore, Cur-HD NPs markedly stimulated apoptosis of osteoclasts. Therefore, we hope that Cur-HD NPs is useful nanodrugs for the treatment of bone-related diseases. |
| 저자 |
박경순1, 이재용2, 김성은2, 윤영필2, 최성욱3, 김학준2, 송해룡2
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| 소속 |
1한국기초과학지원(연), 2고려대, 3가톨릭대 |
| 키워드 |
Osteoclastogenesis; Osteoclast; Curcumin; Heparin nanoparticle
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| E-Mail |
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