| 초록 |
A series of previous in vivo studies demonstrated that self-assembled polymeric complex using polycations effectively deliver the heparin-binding growth factors. Poly(ethylene argininylaspartate diglyceride) (PEAD) that is based on aspartic acid, has been investigated for the development of the self-assembeled delivery complex. Effective delivery of heparin-binding growth factors using this complex will be a promising protein therapeutic strategy. The tertiary structure of growth factor/heparin/polycation has several significant advantages: high encapsulation efficiency, simple fabrication process in aqueous condition, easy usage during medical operations, protection of cargo growth factors in in vivo physiological condition, and sustained release of incorporated growth factors. Therefore, a successful delivery of therapeutic growth factors facilitates tissue regeneration, especially skin tissues. Incision and subsequent sutures during the treatment of cancer resection, C-section, and many cosmetic/plastic surgical procedures often resulted in fibrous tissue formation and scar elevation in skin tissues. Delivery of transforming growth factor-beta3 and interleukin using this polycation complex may reduce the deposition of excess collagen and subsequent scar formation. Development of research plan will be introduced in the presentation. |
