| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
A study of drug content and cell cytotoxicity of paclitaxel-eluting stents coated with various biopolymer |
| 초록 |
In this study, the paclitaxel eluting stent(PES) was prepared by coating a biliary stent with paclitaxel using various biopolymer such as poly(vinyl acetate)(PVAc), poly(lactic-co-glycolic acid)(PLGA), Silicone rubber for restenosis prevention in gastrointestinal disease by a dip-coating method. Drug contents of PES were increased as surface area of stent, concentration and molecular weight of coating polymer increase. In 1H-NMR specta, we know that drug did not change by confirming specific peaks of paclitaxel in PES. As shown in SEM image, PES prepared using various biopolymer is coated clearly and regularly except Silicone rubber coating polymer. In in vitro cell cytotoxicity test, bare stent showed low cytotoxic effect against CT-26 colon carcinoma cell line on 3 day. However, PES coated with PLGA 502H showed the highest cytotoxicity because PLGA 502H is biodegradable polymer and has less molecular weight than other coating polymer. |
| 저자 |
김동곤1, 신일균1, 김한기1, 박종채1, 김상호1, 나재운2
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| 소속 |
1(주)엠아이텍, 2순천대 |
| 키워드 |
Drug eluting stent; Paclitaxel; Biopolymer; Restenosis; Drug contents
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| E-Mail |
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