| 초록 |
Conjugated polymer nanoparticles (CPNPs) have been regarded as an attractive alternate to conventional small molecular optical probes. In bioapplications, CPNPs can be more utilized through chemical/physical modification of their exterior to impart additional functionality as well as inherent photonic properties. However, typical CPNPs have a surface composed of aromatic structure without active functional sites, which may limit further modification on the surface including conjugation of biomolecules. Here, we devised a set of small peptides containing reactive end-functional groups and a molecular structure with high affinity to aromatic molecular. The advantageous features of the CPNPs in the points of tiny colloidal size, stability, bright/stable fluorescence, and capability for further modifications were evaluated to demonstrate a potential for applications to in vitro diagnostic sensor system with high sensitivity for detection of disease-related specific antibodies. |
