| 학회 |
한국화학공학회 |
| 학술대회 |
2001년 봄 (04/27 ~ 04/28, 연세대학교) |
| 권호 |
7권 1호, p.181 |
| 발표분야 |
공업화학 |
| 제목 |
물-메탄올 혼합용액에서 L-O-L-A (L-ornithine-L-aspartate)의 다형 결정화 거동 |
| 초록 |
L-O-L-A, a pharmaceutical material, is a salt of two amino acids (L-ornithine and L-aspartic acid) and has two crystal forms (a- and b-forms). a-type salt (L-O-L-A monohydrate) may be disadvantageously colored or swelled on preservation for a long period of time. In order to obtain better understanding of solventing-out crystallization, it is essential to evaluate how the supersaturation is created in the system, as well as to determine the metastable zone width as a function of the temperature. The solvent and temperature effect on the crystallization behavior of the polymorphs were investigated in a mixture of water and methanol (MeOH) under agitated crystallization. Finally, experimental data were discussed in terms of the dielectric constant. |
| 저자 |
김예훈1, 함승주2, 구기갑3, 설용건, 정준기
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| 소속 |
1연세대, 2서강대, 3한국생명공학(연) |
| 키워드 |
Solventing-out; L-Ornithine-L-aspatate; Metastable zone width; Polymorph; Dielectric constant
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| E-Mail |
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| 원문파일 |
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