| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Induction of Cardiac-Lineage Primed hMSCs via Nanoporous Polymer Membrane Co-Culture for Myocardial Infarction Treatment |
| 초록 |
Human mesenchymal stem cells (hMSCs) have been considered as a potential treatment for heart diseases such as myocardial infarction. In particular, previous studies show that cardiac-lineage primed hMSCs are known to possess better therapeutic efficacy than naïve hMSCs for myocardial infarction. For the first time in this line of research, we developed a novel stem cell co-culture platform based on biocompatible, highly porous, and ultrathin polymer membranes to control the hMSC behavior toward cardiac lineage by the co-culture of hMSCs with cardiomyoblast cell line (H9C2). After 1 week of co-culture, the cardiac lineage commitment of hMSCs was assessed, showing significantly higher levels of connexin43 and cardiac structural/ion channel biomarkers in the MSCs co-cultured with well-defined nanoporous and ultrathin polymer membranes. |
| 저자 |
류진, 류승미, 장영선, 한진, 김병수, 차국헌
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| 소속 |
서울대 |
| 키워드 |
Cardiac lineage; hMSC; Nanoporous membrane
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| E-Mail |
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