| 초록 |
Stimuli-responsive hydrogels have been widely exploited as a drug delivery system. Hydrogel, especially responding to the magnetic field as a stimulus factor, is called ferrogel and has been utilized to control the release behavior of drug loaded in the gel under the magnetic stimulation. Biocompatible polysaccharide can be a good candidate material for ferrogel fabrication. However, its deformation degree is very small due to the limited porosity of the ferrogel. We thus incorporated gelatin microspheres into alginate ferrogel and increased the temperature to remove the microspheres, which resulted in the enhanced porosity. Doxorubicin was chosen as a model drug and its release from alginate ferrogel with different porosity was monitored in vitro. The therapeutic efficacy was also evaluated using a tumor-bearing mouse model. Porous alginate ferrogel that can release therapeutic drug in a controlled manner under magnetic stimulation may be useful in many biomedical applications. |
