| 초록 |
Three-dimensional (3-D) bioprinting is one of the promising methods to construct functional biological structures for various medical applications, including regeneration of tissue and organ. We previously demonstrated that oxidized hyaluronate (OHA) can form hydrogel in the presence of glycol chitosan (GC) via Schiff base formation. Interestingly, chemical healing of OHA/GC gels can be achieved by addition of adipic acid dihydrazide (ADH) to the gel. In this study, alginate (ALG) was added to OHA/GC/ADH hydrogel and the gel was treated with calcium ions after printing to maintain its stability under physiological conditions. Self-healing OHA/GC/ADH/ALG hydrogel may be useful to fabricate complex tissue structure using a 3-D printer. |
