| 초록 |
Bio-degradable PLAs have been attracting much interest because lactide can be produced from renewable resources, such as starch and corn. Also, the degradability of PLA can be controlled by copolymerization with glycolide, ε-caprolactone, or stereochemical LA. Incorporation of hydrophilic glycolide into PLA, poly(lactide-co-glycolide) (PLGA) has been one of the most attractive polymer materials because of its fast biodegradation due to the absence of methyl group in GA. In this study, a degradation rate of PLGA monolayers was investigated by Langmuir technique as functions of pH, enzyme concentration, and surface pressure in the subphase. Although proteinase K is selectively effective to l-LA unit, PLGA monolayers showed faster enzymatic degradation than l-PLA one, depending on composition. |
