| 초록 |
Nano-aggregates are smaller than typical blood cells, such as erythrocytes or lymphocytes, hence can be possible to circulate long time in bloodstream. In present study, we investigated to make sure the potential of Chitosan-Pluronic® (CP) nano-aggregates as an injectable drug carrier. CP nano-aggregates were prepared by coupling monocarboxy Pluronic® (F127) with chitosan using EDC/NHS chemistry. Drug-loaded CP nano-aggregates were primed by the direct dissolution method. The CAC was approximately 0.993g/L. The nano-aggregates sizes were approximately 80 to 140nm by using DLS. We could confirm the nano-aggregate size with TEM. In vitro release studies were investigated with Indomethacin (IMC) as a model drug. From this drug release profiles, IMC was released sustainedly for about 50hrs from the CP nano-aggregates. These results supported that CP nano-aggregates have a potential as an injectable carrier for controlled drug delivery systems or various biomedical applications. |
