| 초록 |
Mesoporous silica nanoparticles (MSN) as promising drug nanocarriers have become a new area of interest recently due to their unique properties(controllable size, large specific area, high drug-loading capacity, etc.). Particularly, we focus on the stimuli-responsive controlled drug delivery system (DDS) that is able to respond to light. In our work, Prussian blue (PB) and poly(N-isopropylacrylamide) (PNIPAm) is introduced into MSN. PB absorb Near Infrared (NIR) light and convert it into heat energy. NIR can be used as a stimulant for DDS because it minimizes the destruction of normal cells and penetrates deep into the body. Meanwhile, PNIPAm has lower critical solution temperature (LCST) phase transition above 32℃ which is near that of the human temperature. So we designed and synthesized a system that uses photothermal effect (PTE) with a long wavelength of 808 nm and releases the drug by shrinking the polymer when the heat released from PB. |
