| 학회 | 한국재료학회 |
| 학술대회 | 2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 | 22권 2호 |
| 발표분야 | B. 나노화학/바이오 재료 분과 |
| 제목 | Porous collagen/Hydroxyapatite scaffolds with tailored macro/nano porous structure using 3D plotting technique |
| 초록 | In this study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen/hydroxyapatite(HA) scaffolds, particularly comprised of nanofibrous collagen/hydroxyapatite(HA) filaments. In this technique, collagen/hydroxyapatite(HA) filaments deposited in a coagulation bath could be effectively gelled through the self-assembly of collagen molecules into fibrils, accordingly, enabling the 3-dimentional deposition of collagen filaments with a collagen nanofiber network. The unique macro/nano-structure could be structurally stabilized by dehydration process coupled with chemical cross-linking. All the collagen/HA composite scaffolds produced with various HA contents (0 wt%, 10wt%, 15wt%, and 20wt%) showed that straight collagen/HA composite frameworks were well constructed in a controlled periodic pattern. Mechanical properties, such as ultimate tensile strength and elastic modulus, increased remarkably with an increase in HA content. The porous collagen/HA scaffolds had 3-dimentionally interconnected macropores separated by nanoporous collagen/HA filaments. In addition, the macro/nano-porous collagen scaffolds showed the tensile strength of about 353~800 KPa at a porosity of ~ 95vol% and excellent in vitro biocompatibility, assessed using pre-osteoblast MC3T3-E1 cells. |
| 저자 | 김종우, 고영학, 최재원 |
| 소속 | 고려대 |
| 키워드 | collagen / Hydroxyapatite / 3D plotting |
