| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Chitosan-based dual pH and thermal responsive polyelectrolyte hydrogel for colon targeted controlled drug delivery: effect of crosslinker type on drug loading and kinetics release |
| 초록 |
The novel dual pH and thermal responsive hydrogel for colon targeted controlling drug delivery was prepared based on polyelectrolyte network of Polyacrylic acid (PAA) and Norbornene-modified Chitosan (CsNb) simultaneously taken place with chemical cross-linked with bisTetrazine-Poly(N-isopropyl acrylamide) (bisTz-PNIPAM). FTIR, DSC, WAXD and morphological analysis were carried out to demonstrate the successful formation of polyelectrolyte network of –COO- and –NH3+ groups. BisTz-PNIPAM crosslinker performed the outstanding properties in comparison with non-covalent crosslinker and non-polymeric crosslinker system: it inhibited release in acid environment; increased of drug loading content because of more porosity structure and entanglement of PNIPAM chains, and controlled the release based on shrinkage mechanism. |
| 저자 |
이시윤, Hoang Thi Huong, 박한솔, 임권택
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| 소속 |
부경대 |
| 키워드 |
Chitosan; Polyacrylic acid; Polyelectrolyte; Poly N-(Isopropyl acrylamide); thermal responsive; colon targeted drug delivery; inversed electron demand Diels-Adler
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| E-Mail |
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