| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 고분자를 이용한 유전자 전달 |
| 제목 | PEGylated nano-hybrid adenovirus: Retargeting adenovirus to specific cells |
| 초록 | Adenoviruses are commonly used in gene therapy because of high infection efficiency to many cell types. But adenoviruses have several important limitations including inflammation, immune responses, and non-specific gene transfer. Here we report PEGylated adenovirus to overcome the inherent problems associated with viral gene therapy. The surface of adenoviruses was PEGylated with folate-PEG conjugate. PEG on the surface of adenoviruses, can reduce immune response against viral capsid protein. Folate immobilized on the distal chain end of PEG can function as a retargeting moiety to specific folate receptor expressed cells. Gene expression of folate-PEG-Adenovirus was significantly enhanced against a folate receptor over-expressing cell line (KB cells) compared to a folate receptor deficient cell line (A549 cells). |
| 저자 | 오인경, 목혜정, 박태관 |
| 소속 | 한국과학기술원 생명과학과 |
| 키워드 | PEG; folate; adenovirus; retargeting; gene therapy |
