| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Retargeting of Adenoviral Gene Delivery via Herceptin-PEG-Adenovirus Conjugates to Breast Cancer Cells |
| 초록 |
Gene therapy using viral vectors have evolved to become highly efficient for gene delivery to specific cell types while avoiding immunosurveillance by an infected host. Human epidermal growth factor receptor 2 (HER2/neu) overexpressing breast cancer- targeted adenoviral gene delivery is one of the promising strategies for enhancing the transduction efficacy of PEGylated adenovirus (PEG-ADV). The viral capsid of adenovirus carrying the green fluorescent protein (GFP) was conjugated with bifunctional polyethylene glycol (PEG).Then, the surface of PEG-ADV was conjugated with therapeutic monoclonal antibody (MAb), Herceptin (Trastuzumab; HER)to grant cell specific targeting. The PEG-ADV and Herceptin immobilized PEG-ADV (HER-PEG-ADV) were evaluatedtheir extents of retargeting, as compared to those of naked ADV. |
| 저자 |
정유경, 함승주, 박효진, 양재문, 이재원, 혀용민
|
| 소속 |
연세대 |
| 키워드 |
Adenovirus; PEG; Herceptin; Targeting; Gene therapy
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| E-Mail |
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