| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Delivery of antisense oligonucleotides using multi-layer coated gold nanoparticles for targeting multidrug-resistant bacteria |
| 초록 |
The spread of multidrug-resistant (MDR) bacterial infections has become a serious global threat. Nanoparticle-based gene delivery systems that inhibit the expression of target genes provide novel treatment options to combat multidrug-resistant bacterial infections with high selectivity. We introduce multi-layer coated gold nanoparticles (MLGNPs) delivering antisense oligonucleotides (ASO) targeting the resistance gene mecA of methicillin-resistant Staphylococcus aureus (MRSA) by restoring susceptibility. The delivery of MLGNPs into MRSA resulted in up to 74% silencing of the mecA gene with high selectivity, in a dose-dependent manner. The treatment of MLGNPs to MRSA in the presence of oxacillin, showed major suppression (~71%) of bacterial growth. The current approach can be potentially applied for targeting various types of MDR bacterial infections by specific silencing of a resistance gene, as a combinatorial therapeutic used with conventional antibiotics. |
| 저자 |
Marcel Janis Beha, 정현정
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| 소속 |
카이스트 |
| 키워드 |
Nanoparticle-based drug delivery; gene silencing; multidrug-resistant bacteria
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| E-Mail |
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