| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
BMP-2-Loaded Porous Membrane with Leaf-Stacked Structure as a GBR membrane |
| 초록 |
In this study, we develop an asymmetrically porous membrane with leaf-stacked structure (LSS membrane; top with nano-sized pores and bulk/bottom with leaf-stacked structure) by an immersion-precipitation method using polycarprolactone (PCL)/Pluronic F127 mixture solution (in tetraglycol). The bone morphogenetic protein-2 (BMP-2) is immobilized on the pore surfaces of the LSS membrane by immersion of the membrane in the BMP-2 solution. The BMP-2 immobilized in the LSS membrane is continuously released up to 38 days (without additional modifications of the matrix) to accelerate osteogenic differentiation of human periosteum-derived cells (hPDCs) and bone regeneration (carvarial defect rat model). It is also recognized that the leaf-stacked structure itself can be a physical stimulus for bone regeneration, and the stimulation effect is comparable with the continuously released BMP-2. Moreover, we observe the combined effect of BMP-2 and leaf-stacked structure for bone healing. |
| 저자 |
박진현1, 김호용1, 변준효2, 이진호1, 오세행1
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| 소속 |
1단국대, 2경상대 |
| 키워드 |
Bone regeneration; BMP-2; GBR membrane; leaf-stacked structure
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| E-Mail |
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