| 초록 |
Over the past few years, thermogelling polymers that undergo sol–gel transition in aqueous media as the temperature increases have been extensively studied for various biomedical applications, especially for drug delivery and tissue engineering. In this study, a series of acylated glycol chitosans (AGCs) have been synthesized by N-acylation of glycol chitosan and evaluated as a new polysacchride-based thermogelling system that may overcome the limitations with the current synthetic polymer based thermogel systems. Also, various AGCs-based thermo-gelling systems with different physicochemical properties and biological fuctionalities have been developed for diverse biomedical applications, including 3D cell spheroid formation, ocular delivery system, mucoadhesive delivery system, cell encapsulation, and treatment of degenerative disc disease. |
