| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fabrication and analysis of absorbable powder-type hemostatics containing blood coagulation factors |
| 초록 |
Absorbable chitosan (Cs)/starch (St) powder offers a wide range of fascinating benefits such as easy handling, biocompatibility, blood coagulability. In this study, we fabricated to use as a powder-type absorbable hemostatic agent containing CaCl2 and thrombin. The crosslinked structure and morphology were determined using FTIR and SEM. In vitro whole blood coagulation experiment showed rapid blood coagulation within one minutes after introduction with fabricated powder-type hemostatic because of absorption by providing calcium ion and thrombin. In vivo animal studies using haemorrhaging liver rat model showed that the Cs/St/CaCl2/thrombin group reduced bleeding time and hemorrhage quantity than control and commercial products groups. The powder-type Cs/St/CaCl2/thrombin hemostatics have excellent hemostatic activity and biocompatibility properties for use in clinical hemostasis applications. |
| 저자 |
신인해, 김유진, 권오형
|
| 소속 |
금오공과대 |
| 키워드 |
hemostatics; powder-type; wound; wound healing; blood
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| E-Mail |
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