| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of Extracellular Matrix on PLGA Film to Rabbit Corneal Endothelial Cells |
| 초록 |
Corneal endothelium is mono-inner cell layer of cornea and lay on Descmet’s membrane (DM). DM is comprised of various proteins called extracellular matrix including fibronectin, collagen, laminin and proteoglycan. The extracellular matrix can directly affect the cellular behaviors such as cell adhesion, proliferation, polarity, morphogenesis and functional expression. In this study, we investigated the rabbit corneal endothelial cells with poly(lactide-co-glycolide) (PLGA) film surfaces coated with various cell-adhesive molecules like fibronectin, laminin, collagen type IV, collagen type I and FNC coating mix. We studied morphologic images, cell proliferation assay, adhesion assay, immunofluorscence and RT-PCR. The results of this study showed that the behaviors of rabbit corneal endothelial cells were affected by cell-adhesive molecules. This research was supported by WCU (R31-20029) and SCRC (SC4110). |
| 저자 |
조수진1, 김은영1, 최진산1, 송정은2, 주천기1, 이동원3, 강길선1
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| 소속 |
1전북대, 2wake forest Univ., 3가톨릭대 |
| 키워드 |
Extracellular matrices (ECM); Rabbit Corneal endothelial cells (rbCEC); PLGA film
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| E-Mail |
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