| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Ion releasing nanoparticles controlling the osteogenic cellular microenvironment in human mesenchymal stem cells |
| 초록 |
In this study, we have developed a metal ion-releasing nanoparticle for enhanced osteogenic differentiation of human mesenchymal stem cells (hMSCs). In order to enhance the osteogenic differentiation and induce angiogenesis of hMSCs, zinc and iron were synthesized simultaneously into a nanoparticle with pH-sensitive degradation property. Our studies revealed that treating optimized concentration of our nanoparticles to hMSCs delivered zinc and iron ion in a controlled release manner and supported early osteogenic gene expression with improved angiogenic paracrine factor secretion. Concurrent intracellular release of zinc and iron ions through the endocytosis of the nanoparticles further stimulated the mild reactive oxygen species generation level in hMSCs without cytotoxicity and thus improved the osteogenic capacity of the stem cells. Current results suggest that our ion releasing nanoparticles might support the future biomedical applications for bone regeneration. |
| 저자 |
김유진1, 이재영2, 임광범1, 송지훈1, 유태경2, 방석호1
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| 소속 |
1성균관대, 2경희대 |
| 키워드 |
Zinc-based iron oxide nanoparticles; zinc ion; iron ion; Mesenchymal stem cells; osteogenic differentiation; angiogenesis
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| E-Mail |
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