| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 봄 (04/19 ~ 04/20, 울산 롯데호텔) |
| 권호 |
13권 1호, p.401 |
| 발표분야 |
생물화공 |
| 제목 |
Hinokitiol-loaded lipid nanoparticles for dermal delivery |
| 초록 |
The aim of this study was to evaluate lipid nanoparticles as the topical carrier for dermal delivery of Hinokitiol(HKL). The melt-homogenization was employed to prepare HKL-loaded lipid nanoparticles(HKL-LN). The HKL-LN size was determined by electrophoretic light scattering spectrophotometer. The HKL-LN has low average size between 30 and 200nm. EF-TEM(energy filtering transmission electron microscopy) image showed that the HKL-LN has a spherical shape. The HKL-LN was applied onto the skin of hairless mouse in the Franz diffusion cell. The permeation of the HKL that incorporated in lipid nanoparticles was 10-fold higher than that HKL and propylene glycol mixture. These results revealed that the HKL-LN may be a prospective carrier for dermal delivery of HKL. |
| 저자 |
주향희, 조성민, 김진철
|
| 소속 |
강원대 |
| 키워드 |
lipid nanoparticles; dermal delivery; hinokitiol
|
| E-Mail |
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| 원문파일 |
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