| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.654 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Biodegradable Temperature Sensitive MPEG-PCL Copolymer Hydrogels |
| 초록 | Temperature-sensitive polymer have been investigated extensively for the drug delivery system and tissue engineering. Especially, biodegradable thermo-reversible hydrogels has many characters such as good solubility in water, easy drug loading, non-toxicity, and biodegradability. Recently PEG-based diblock and triblock polyester copolymers, stimulating to temperature, were studied as injectable drug delivery and tissue regeneration.1,2 In this study, to prepare thermo-reversible sol-gel polymers, we synthesized the diblock copolymer consisting of methoxy polyethylene glycol (MPEG) and ε-caprolactone (ε-CL) by ring opening polymerization in the presence of HCl․Et2O at room temperature. The concentrated PBS solution of MPEG-PCL diblock copolymers changed from sol to gel phase as the temperature increased. Also, we observed protein release of 20 wt% PBS solutions loading 0.1 % bovine serum albumin, dextran, and insulin. Hydrogels containing proteins showed the sustained release behavior without the initial burst. To confirm the gel formation at body temperature, we observed the mice after injection of 20 wt% aqueous solution of block copolymer. After two months, we confirmed the gel on mice without the dispersion of gel. In conclusion, we confirmed that these MPEG-PCL diblock copolymers have possibility for the biomedical applications as injectable drug delivery carrier and tissue engineering via in situ gel formation. Acknowledgement: This work was supported by KMOHW (0405-BO01-0204-036). References 1. C. Allen, Y. Yu, D. Maysinger, and A. Eisenberg, Polycaprolactone-b-poly(ethylene Oxide) Block Copolymer Micelles as a Novel Drug Delivery Vehicle for Neurotrophic Agents FK506 and L-685,818, Bioconjug Chem , 9, 564 (1998). 2. J. W. Lee, F. Hua, and D. S. Lee, Thermoreversible gelation of biodegradable poly(-caprolactone) and poly(ethylene glycol) multiblock copolymers in aqueous solutions, J Controlled Release , 73, 315 (2001). |
| 저자 | 서광수1, 현훈2, 김문석1, 조선행1, 강길선2, 이해방1 |
| 소속 | 1한국화학(연), 2전북대 |
| 키워드 | temperature sensitive; MPEG-PCL; hydrogels |
