| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and Characterization of Poly(ethyleneglycol)-Poly(s-dodecyl cysteine) Block Copolymer Micelles as Carriers for Water-Insoluble Drugs |
| 초록 |
The diblock copolymers composed of poly(ethylene glycol) as hydrophilic block and poly(s-dodecyl cysteine) as hydrophobic block are synthesized by ring opening polymerization of s-dodecyl cysteine N-carboxyanhydride using monomethoxy-poly(ethylene glycol)amine as macroinitiator, which were characterized by 1H NMR, Fourier transform infrared (FT-IR), and gel permeation chromatography (GPC). The critical micelle concentrations (CMC) of copolymers were measured, which were of the order of 10-6 M. In addition, indomethacin loaded polymeric micelles were prepared with various ratios of polymer to drug using the oil-in-water emulsion technique. The volume weight diameters, drug loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume weight diameters of polymeric micelles ranged from 40 nm to 130 nm and were distributed for drug delivery system. |
| 저자 |
김현철1, 민영훈2, 도미애1, 이세근1, 이성준1, 김은주1, 백철수1, 이승우2, 정상원1
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| 소속 |
1대구경북과학기술원, 2영남대 |
| 키워드 |
polymeric micelles; drug delivery
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| E-Mail |
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