| 초록 |
The acyllipid-PEG conjugate composed of stearoyl groups as hydrophobic block containing disulfide bond was prepared for the formation of micelles. The critical micelle concentration (CMC) was determined with pyrene probe and its CMC was 9.3 ⅹ10-7 M in water. Indomethacin (IMC) as a model drug was incorporated into the micelle by an oil/water emulsion method. A mean diameter of micelle formed was 43.9 nm, and its size increases because of the IMC encapsulated into the inner core of acyllipid-PEG conjugate. The drug release from IMC-loaded acyllipid-PEG conjugate micelle was investigated as a function of glutathione concentration in the release medium. The release study revealed that the IMC release from acyllipid-PEG conjugate micelle increased with increasing the gluthathione concentration, and indicated that the IMC release from micelle can be controlled by adjusting glutathione concentration, demonstrating their potential as drug delivery vehicles. |
