| 학회 |
한국화학공학회 |
| 학술대회 |
2008년 봄 (04/23 ~ 04/25, 제주ICC) |
| 권호 |
14권 1호, p.297 |
| 발표분야 |
분리기술 |
| 제목 |
Chiral Recognition of Mandelic Acid on Quartz Crystal Microbalance by Vapor Diffused Molecular Assembly Method |
| 초록 |
Chiral recognition plays important roles in pharmaceutical and biotechnology fields. The key step for selectively sensing chiral compounds is to build a chiral surface with recognition sites to enantiomers. In this study we report a new approach for highly selective recognition of chiral L- / D-mandelic acid (MA) by quartz crystal microbalance (QCM), using L-phenylalanine (L-Phe) as the selector. The immobilization of L-Phe on the gold surface of QCM electrode was performed by using a four steps layer-by-layer assembling procedure. The modification of the gold surface of the QCM sensor after each modification step was verified by cyclic voltammetry, contact angle, FTIR, and QCM detection. The chiral recognition ability of L- / D-MA on this chiral surface was checked by sensing them using vapor diffused molecular assembly method by QCM. The chiral discrimination factor between L- and D-MA, α L-MA/D-MA, was found to be about 9. The high chiral discrimination ability of the modified surface could be the result of the different hydrogen binding force between L- or D-MA and L-Phe. |
| 저자 |
Hui-shi Guo1, 김종민2, 장상목3, 김우식3
|
| 소속 |
1경희대, 2Shaoguan Univ., 3동아대 |
| 키워드 |
Quartz Crystal |
| E-Mail |
|
| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
