| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
(생물공학) 생물전환기술 현황과 전망 |
| 제목 |
pH-triggered release of manganese from MnAu nanoparticles that enables cellular neuronal differentiation without cellular toxicity |
| 초록 |
Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn2+ release from AuNPs was designed to be pH-responsive so that low pH condition of the cell endosomes can trigger in situ release of Mn2+ from AuNPs after cellular uptake of Mn-incorporated AuNPs (MnAuNPs). Due to the differences in reduction potentials of Mn and Au, only Mn ionized and released while Au remained intact when MnAuNPs were uptaken by cells. Compared to PC12 cells treated with a high concentration of free Mn2+, PC12 cells treated with an equal concentration of MnAuNPs resulted in significantly enhanced cellular neurodevelopment with decreased apoptosis and necrosis. |
| 저자 |
방석호1, 유태경2, 김병수3
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| 소속 |
1성균관대, 2경희대, 3서울대 |
| 키워드 |
Drug delivery; Gold nanoparticle; Manganese ion; Neuronal differentiation; Pheochromocytoma cell
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| E-Mail |
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