| 초록 |
We focused on the biophysical guidance, which was provided similar topographical cues to cellular environment, to recruit host cells for bone defect healing. In this study, we hypothesized that nanotopographical features enhanced cell recruitment, migration and differentiation from intact cells without additional stimulation. We designed a biodegradable and transplantable poly (lactic-co-glycolic acid) nanopatterned patch and confirmed that biodegradable nanopatterned patch (BNP) accelerated migration of osteoblast in vitro, bone regeneration at defect site in vivo according to orientation of patterned direction. The BNP with biophysical guidance should be suitable utilized for tissue regeneration by accelerated intact cell migration. |
