| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 | 25권 2호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | One-Pot Synthesis of a Polymeric Contrast Medium for Ideal Computed Tomography |
| 초록 | Computed tomography (CT) is widely used for diagnosis and treatment of disease due to its deep penetration capabilities and easy post-image processing techniques. Moreover, contrast agents are used to obtain better contrast effects of CT, but conventional iodinated monomolecular CT agents are difficult to obtain accurate imaging by problems such as low radiation density, solubility in blood, high osmolality, and toxicity. In this study, we synthesized Iodine-sealed carbon particles (ISCP) through one-point synthesis to solve these problems. ISCP is a molecular composite of triiodobenzene and hydrophilic linker, glycerol. ISCP was made with One-pot Synthesis without organic solvent and catalyst showed good hydrophilicity. We demonstrated a good contrast effect of ISCP compared to conventional iodinated CT agents in same concentration Also, ISCP exhibited no cytotoxicity, no acute toxicity, and high biocompatibility through the in vitro test and in vivo test. |
| 저자 | 최장호, 정요한, 신희준, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | computed tomography contrast medium; biocompatible |
