| 초록 |
The crystallization process of drugs is an important unit operation in the pharmaceutical industry. Crystalline structures are often constructed by assembly and/or transformation from smaller units. It has been found that the morphology of polar organic crystals could be changed by the addition of oppositely charged polymeric additives, which can physically adsorb onto the surface of the smaller crystal units. To understand the role of polymer adsorption, the crystallization of atorvastatin calcium was performed in methanol/water mixture. PEI, chitosan, bio-synthesized elastinlike polymers and PAA were used as polymeric additives. This polymer-directed crystallization resulted in the formation of mesocrystals, artificially stabilized by polymeric additives. Interesting morphological features were observed in the mesocrystal cases. This polymer-directed crystallization resulted in the formation of mesocrystals, artificially stabilized by polymeric additives. |
