| 초록 |
Recently, in tissue engineeringGellan gum as a polysaccharide composed of glucose, glutaric acid, and rhamnose is proposed as a substitute forcartilage regeneration applications. Silk Fibroin has biocompatibility, biodegradability and excellent mechanical properties. In this work, to confirm the effect of silk fibroin on cartilage regeneration, hydrogel scaffold was prepared by using 2wt% silk fibroin(SF)/ 2wt% Gelln gum(GG) at weight ratio of 100/0, 70/30, 50/50. The characterizations of scaffolds were implemented by FT-IR, Compressive strength, porosity, and SEM. Cell proliferation and gene expression were evaluated by MTT, Bio-SEM, RT-PCR. As a result, SF50/GG50 scaffold was confirmed as excellent scaffoldfor cartilage tissue regeneration. This research was supported by a grant of the Korea Health Technology R&D Project through KHIDI (HI15C2996 ). |
