| 학회 |
한국화학공학회 |
| 학술대회 |
2017년 가을 (10/25 ~ 10/27, 대전컨벤션센터) |
| 권호 |
23권 2호, p.1684 |
| 발표분야 |
생물화공 |
| 제목 |
Design and applicaitons of silica-forming petides |
| 초록 |
Silica with nontoxic and highly biocompatible characteristics can be applied for tissue scaffolds, drug-delivery system, biosensors and imaging. For silica synthesis, conventional methods typically require a combination of high temperatures and extreme pH and also it is difficult to prepare controlled structures. However, the discovery of the critical molecules involved in biosilicifica found both in diatoms (silaffins and polyamines) and sponges (silicateins) brings out understandings about silica forming process in vivo and has presented a new paradigm for silica synthesis under ambient or mild conditions. Here, we reported new silica-forming peptides (SFP), named EctP1 and EctP2. They were also genetically fused to the terminus of target protein. The resultant SFP-fused proteins show silicification ability and silicified SFP-fused protein exhibited an organic-inorganic complex form. These results indicate that the SFP fusion system is a novel tool for immobilizing biomolecules on silica material for biological and industrial applications. |
| 저자 |
백승필, 김성호, 여기백, 기미란, Thi Khoa My Nguyen
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| 소속 |
고려대 |
| 키워드 |
생물화공 |
| E-Mail |
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| 원문파일 |
초록 보기 |
