| 학회 | 한국재료학회 |
| 학술대회 | 2009년 가을 (11/05 ~ 11/06, 포항공과대학교) |
| 권호 | 15권 2호 |
| 발표분야 | D. Health and Biological Materials(생체 및 의용재료) |
| 제목 | In vitro biocompatibility of a cement composite containing poly (ε-caprolactone microsphere) (PCL) |
| 초록 | In recent years, it has been tried to develop the efficacy and bioactivity of Calcium Phosphate cements (CPC) as injectable bone substitute (IBS) by reinforcing them through varying the amount in its compositions and relative concentrations or adding other additives. In this study, the biocompatibility of a reinforced Calcium Phosphate-Calcium Sulfate injectable bone substitute (IBS) containing poly (ε-caprolactone) PCL microspheres was evaluated which consisted of solution chitosan and Na-citrate as liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate anhydrous (DCPA) powder as the solid phase. The in vitro biocompatibility of the IBS was done using MTT assay and Cellular adhesion and spreading studies. The in vitro experiments with simulated body fluid (SBF) confirmed the formation of apatite on sample surface after 7 and 14 days of incubation in SBF. SEM images for one cell morphologies showed that the cellular attachment was good. MG-63 cells were found to maintain their phenotype on samples and SEM micrograph confirmed that cellular attachment was well. In vitro cytotoxicity tests by an extract dilution method showed that the IBS was cytocompatible for fibroblast L-929. |
| 저자 | Md. Anirban Jyoti1, Young-Ki Min2, Byong-Taek Lee3, Ho-Yeon Song2 |
| 소속 | 1Dept. of Immunology, 2Soonchunhyang Univ., 3Dept. of Physiology |
| 키워드 | Bioactivity; CPC; IBS; Microspheres; Biocompatibility |
