| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
The Growth Behavior of Retinal Pigment Epithelial Cellson SIS/PLGA Film |
| 초록 |
Several transplantation of retinal pigment epithelium(RPE) cells can causes degeneration. Thus, transplantation of cell in human needs a suitable scaffold. In the present study, we prepared the SIS/PLGA films and investigated to determine their suitable films for rabbit RPE cells culture. Porcine SIS derived from the submucosal layer of porcine intestine, both generate a minimal inflammatory response following implantation and have been approved for many types of biomedical applications. We fabricated biomaterial hybrid films using SIS into PLGA. Then RPECs were seeded on SIS/PLGA film. In the result of MTT assay, cell viability on SIS/PLGA films was higher than bFGF/PLGA films and PLGA films. RPEs specific mRNA expression and protein could not be observed on SIS/PLGA film. SIS provides suitable surface to RPEs and SIS of suitable content affect to improve cell adhesion and phenotype maintenance. This research was supported by WCU(R31-20029), MBC(0405-BO01-0204-0006) and SCRC (4110). |
| 저자 |
정수미, 조수진, 조은혜, 이가영, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Small Intestinal Submucosa; PLGA; Retinal Pigment Epithelium
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| E-Mail |
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