| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
In Vivo Release of Bovine Serum Albumin From a Small Intestinal Submucosa Gel |
| 초록 |
Delivery systems capable of maintaining a sustained release of protein drugs at specific sites can potentially circumvent problems of toxicity and subtherapeutic local dosing levels associated with systemic administration. Small intestinal submucosa (SIS) derived from the submucosa layer of porcine intestine has widely used as biomaterial with minimum immune response. Here, we explored the potential utility of an injectable SIS gel as a drug depot for bovine serum albumin (BSA). BSA loaded SIS solutions were prepared at room temperature. The solution was gelled when subcutaneously injected into rats, then forming three-dimensional network structure that showed sustained release of BSA for 20 days in vivo. Then BSA-loaded SIS gels was higher BSA bioavailability than BSA only solutions. SIS gel did not provoke a significant inflammatory response. Thus, injectable SIS gel system may provide numerous benefits as a minimally invasive therapeutics drug depot. |
| 저자 |
강꽃님, 윤소미, 김경해, 김이슬, 서효원, 김재호, 민병현, 김문석
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| 소속 |
아주대 |
| 키워드 |
Drug delivery system; small intestinal submucosa
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| E-Mail |
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