| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Induction of chondrogenic differentiation of adipose-derived stem cell(ASC) using F127-based hydrogel |
| 초록 |
Human adipose-derived adult stem cells (ASC) have the ability to differentiate into a chondrogenic phenotype in three-dimensional culture and media containing dexamethasone (Dex) and transforming growth factor (TGF). The purpose of this study is to make a Pluronic-based hydrogel, in which hydrogel can carry a specific functionality toward the induction of chondrogenic differentiation of ASC without exogenously added chondrogenic supplements. In this work, a Pluronic (F127,F) derivative (FGM) was synthesized using glycolide (G) and 4-methacryloxyethyl trimellitic anhydride (META, M). To add functionality, Dex and heparin (Hep) are grafted to the Pluronic derivative,producing FGM-Hep and FGM-Dex. For in vivo test, ASC was mixed with Pluronic-based hydrogels containing TGF and Dex. The results of nude mouse implantation for 4 weeks suggested that functional Pluronic-based hydrogel has a potential as an injectable system in stimulating chondrogenesis of ASC. |
| 저자 |
정홍희1, 박귀덕1, 김병수2, 안광덕1, 한동근1
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| 소속 |
1한국과학기술(연), 2한양대 |
| 키워드 |
ASC; Pluronic F127; Termosensitive hydrogel; TGF-β1; Dexamethasone; chondrogenesis
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| E-Mail |
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