| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Cartilage tissue engineering using TGF-β1 loaded functional PLGA nanoparticles and a elastic PLCL scaffold |
| 초록 |
In cartilage tissue engineering, the chemical and mechanical stimulations are very important for differentiation and maintenance of the lineage. Also, 3-dimensional spatial organization of cells is crucial to functional cartilage formation. We formed substantial tissue engineered cartilage with human adipose derived stromal cells (hADSCs) and TGF-β1 loaded functional nanoparticle–hydrogel-Polymer complex. We used mechano-active scaffolds of poly(lactide-co-caprolactone) (PLCL) having a complete rubber-like elasticity and functional nanoparticles made with poly(lactide-co-glycolide) (PLGA) as a hydrophobic core, Pluronic F-127 as a hydrophilic surface layer, and heparin as the functional moiety. The hybridization of a gel and a PLCL scaffold and TGF-β1 loaded nanoparticles with continuous controlled release can encourage hADSCs to differentiate to chondrocytes, maintain their phenotypes and enhance GAGs production and consequently, improve the quality of cartilaginous tissue formed. |
| 저자 |
정영미1, 김상희1, 정용일2, 태기융2, 김상헌1, 김영하2, 이종원3, 김수현1
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| 소속 |
1한국과학기술(연), 2광주과학기술원, 3카톨릭대 |
| 키워드 |
cartilage tissue engineering; TGF-β1; nanoparticles; human adipose derived stromal cells
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| E-Mail |
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