| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Chondrocyte Culture Using a Nanofiber-Hydrogel Composite System |
| 초록 |
Cartilage is a flexible connective tissue covering the end part of bones in joints. Cartilage has a limited capacity for self-repair. Therefore, tissue engineering approach is necessary for the treatment. In this study, a nanofiber-hydrogel composite system has been investigated as a cell and growth factor carrier for cartilage tissue engineering applications. Rabbit articular chondrocytes and transforming growth factor-β1 (TGF-β1) were mixed with the precursors of a heparin-based hydrogel. The mixture was then seeded onto a roll-type scaffold made of electrospun PLCL/gelatin fibers. The nanofiber-hydrogel composite system showed more improved cell seeding efficiency and enhanced chondrocyte-specific gene expression by real-time RT-PCR than those prepared without hydrogel. Results indicate the potential of the PLCL nanofiber-heparin hydrogel composite system for cartilage tissue engineering. Acknowledgement: Financial support by Research Center for Biomolecular Nanotechnology, GIST |
| 저자 |
홍보희1, 김미혜1, 이종만1, 전장수2, 김영하1, 태기융1
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| 소속 |
1광주과학기술원 생체적용나노기초기술연구센터 / 광주과학기술원 신소재공학과, 2광주과학기술원 생체적용나노기초기술연구센터 / 광주과학기술원 생명과학과 |
| 키워드 |
Chondrocyte; PLCL nanofiber-heparin hydrogel; Cartilage tissue engineering
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| E-Mail |
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