| 초록 |
Tissue engineering is an interdisciplinary field that has attempted to restore or regenerate tissues and organs by biomimetic fabrication of scaffolds with functionality. Graphene oxide (GO) has been considered as a potential biomaterial because of its large surface area, nontoxicity, high dispersibility and hydrophilicity. In this study, we examined the osteogenic potential of C3H10T1/2 cells on GO substrates. GO substrates were fabricated via chemically immobilizing GO at 1.0 mg/ml on glass slides. Osteogenic differentiation of C3H10T1/2 cells on GO substrate resulted in enhanced cellular adhesions and osteogenic differentiation. In addition, osteogenically primed cells with chondrocyte-conditioned medium (CM) were plated on GO substrate, and additive osteogenic responses were observed. All these data suggest that GO substrate along with CM priming will have great potentials as osteogenesis promoting factors. |
