| 초록 |
Despite a potential ability of mesenchymal stem cells (MSC) for myocardial infarction (MI) treatment, the poor survival of implanted MSCs has significantly limited the therapeutic efficacy. Reactive oxygen species (ROS), generated in the ischemic myocardium after the restoration of blood flow, causes the death of implanted MSCs by inhibiting the adhesion of the MSCs to extracellular matrices at the lesion site. In this study, graphene oxide (GO) flakes were used to protect the implanted MSCs and thereby improve the therapeutic efficacy. GO can adsorb extracellular matrix (ECM) proteins and MSCs, having adhered to ECM protein-adsorbed GO flakes, exhibited improved viability and engraftment in vitro and in vivo compared to unmodified MSCs. The adhesion of MSCs to GO flakes prior to implantation enhanced the paracrine secretion, which in turn promoted cardiac tissue repair and cardiac function restoration. |
