| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
International Symposium for Theranostic Macromolecules |
| 제목 |
Molecular shielding of genetically engineered pancreatic islets for xenotransplantation |
| 초록 |
Pancreatic islet transplantation is one of the most promising strategies for patients suffering from type 1 diabetes mellitus, but several therapeutic immunosuppressive medications must be administered simultaneously to protect transplanted islets, and these expose patients to the risk of serious complications. Furthermore, any protocol that combined several kinds of drugs could not prevent immune reactions for a long-term period. This study proposed a new combinational protocol with surface camouflage using PEG with drug treatments such as CsA and CoCl2. The surface camouflage using PEG could prevent the infiltration of immune cells into the transplanted islets, and CsA could prevent the expression of cytokines. CoCl2 could stimulate the over-expression of HO-1, thereby preventing the acute inflammation. |
| 저자 |
변영로 |
| 소속 |
WCU Department of Molecular Medicine and Biopharmaceutical Sciences |
| 키워드 |
type-1 diabetes; pancreatic islets; xenotransplantation; PEG modification
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| E-Mail |
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