| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.259 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Peripheral Nerve Regeneration by Hydrophilic PLGA/Pluronic Nerve Guide Conduit |
| 초록 | Restoration with sufficient functional recovery after peripheral nerve injury continues to be a clinical challenge. Artificial nerve guide conduit (NGC) to bridge the gap between severed nerve stumps is widely accepted as a useful alternative that creates a favorable microenvironment for axonal regeneration, is free of the limitations of natural grafts, and requires no immunosuppressants.1 In our previous study, we developed a novel method to fabricate a NGC with the porosity of submicron pore sizes (to prevent fibrous tissue invasion) and hydrophilicity (for effective oxygen and nutrient permeation) using poly(lactic-co-glycolic acid) (PLGA) and Pluronic F127 by a modified immersion precipitation method designed by our laboratory.2 We recognized that the PLGA/F127 (3 wt%) tube can be a good candidate as a NGC from the analyses of its morphology, hydrophilicity, and model nutrient permeability. In this study, we conducted animal study to estimate nerve regeneration through the hydrophilic PLGA/F127 (3 wt%) tube as a NGC using rat model (sciatic nerve injury) (그림 1, 2). The blank (without tube) and hydrophobic PLGA tube fabricated by the same method were also examined as control groups. The nerve regeneration was investigated by histological observation (H&E, Toluidine blue staining), immunohistochemistry (anti-neurofilament antibody) and analysis of footprint recording (sciatic function index). Acknowledgment This work was supported by a grant from the Korea Ministry of Science and Technology (Grant No. RO5-2004-000-12629-0). References 1. V. Maquet, et al., J. Biomed. Mater. Res., 52, 639 (2000). 2. S. H. Oh and J. H. Lee, Transactions, 7th World Biomaterials Congress, P. 1558 (Sydney, Australia; May 17-21, 2004). |
| 저자 | 오세행1, 윤진환1, 길성호2, 이진호1 |
| 소속 | 1한남대, 2경기대 |
| 키워드 | Nerve guide conduit (NGC); Biodegradable polymer; Hydrophilicity; PLGA; Pluronics |
