| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Guided Tissue Regeneration of Rabbit Calvarial Defect using Silk Fibroin Nanofiber-Poly(glycolic acid) Hybrid Scaffold |
| 초록 |
Tissue engineering aims regeneration of defected biological tissues and organs by combining cells, scaffolds, and growth factors. We prepared patient-customizable guided bone regeneration (GBR)/guided tissue regeneration (GTR) hybrid scaffolds by electrospinning and 3D printing techniques. Poly(glycolic acid) (PGA) scaffolds were fabricated using a 3D printer. The microstructure of silk fibroin nanofiber and PGA scaffolds was observed by SEM. Cell proliferation of osteoblasts on a PGA scaffold was analyzed by MTT assay. Rabbit calvarial defect model was used for animal test. Regenerated tissues were analyzed by Masson Trichrome staining and micro-CT. Silk fibroin-PGA scaffold groups showed significant regeneration of bone compared to control groups. The silk fibroin nanofiber-PGA scaffold construct will provide a prospective approach for regeneration of bone defects |
| 저자 |
여태균, 고영광, 이경우, 김동진, 권오형
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| 소속 |
국립금오공과대 |
| 키워드 |
3D 프린팅; 전기방사; 차폐막; 임플란트; 골유도재생술(GBR); 조직유도재생술(GTR)
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| E-Mail |
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