| 학회 |
한국화학공학회 |
| 학술대회 |
2014년 봄 (04/23 ~ 04/25, 창원컨벤션센터) |
| 권호 |
20권 1호, p.408 |
| 발표분야 |
생물화공 |
| 제목 |
Novel pathway design for the production of high value-added chemicals |
| 초록 |
There have been many efforts in developing systematic platforms to predict novel metabolic pathways for the efficient production of industrially desirable chemicals. In this trend, we developed a systematic framework that generates metabolic pathways along with their candidate enzymes through a prioritization process in order to identify feasible novel pathways for the target chemicals. The systematic framework consists of two parts, route generation and prioritization process. The novel synthetic pathways for the three chemicals, isobutanol, 3-hydroxypropionate (3HP) and butyryl-CoA, were predicted using our system to evaluate the capacity and reliability of the framework. [This systematic framework should be an additional resource useful for the practice of synthetic biology and metabolic engineering. [This work was supported by the Technology Development Program to Solve Climate Changes (systems metabolic engineering for biorefineries) from the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea (NRF-2012-C1AAA001-2012M1A2A2026556)] |
| 저자 |
김동인, 조아연, 윤홍석, 박진환, 이상엽, 박선원
|
| 소속 |
카이스트 |
| 키워드 |
reaction rule set; enzyme candidate; metabolic pathway
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| E-Mail |
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| 원문파일 |
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