| 초록 |
Thermosensitive poly(organophosphazenes) bearing α-amino-ω-methyl-PEGs(AMPEGs), some hydrophobic amino acid esters such as isoleucine ethyl ester (IleOEt), leucine ethyl ester, and valine ethyl ester, and a depsipeptide (ethyl-2-(O-glycyl)glycolate) as side groups have been synthesized. Most of the poly(organophosphazenes) synthesized showed sol-gel transition properties in an aqueous solution. The gelation properties of the polymers were dependent on several factors like the composition of substituents, the chain length of AMPEG, and kinds of amino acid esters. The gelation of the polymers seemed to be imparted by association of hydrophobic groups of amino acid esters. The polymers decomposed in the physiological condition. The application of these polymer gels to a drug delivery system and a tissue engineering will be discussed. |
