| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 |
29권 2호, p.372 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Injectable tissue engineering using thermosensitive polyphosphazene gels. |
| 초록 |
Thermosensitive poly(oganophosphazenes) with α-amino-ω-methoxy-poly(ethylene glycol)(AMPEG), L-isoleucine ethyl ester, and glycyl-glycine allyl ester as side groups have been synthesized. After deprotection of allyl ester groups, activated carboxylic acid groups were conjugated with GRGDS as a bioactive peptide. These poly(oganophosphazenes) with GRGDS conjugates showed thermosensitive sol-gel transition in aqueous solution. These polymer gels were investigated as encapsulation matrices for cell to access their applicability in promoting tissue engineering. Thermosensitive polymer gels with adhesive RGD peptide sequences may enhance the cell attachment and may improve their ability to regenerate tissue more efficiently. These polymer gels having RGD peptide will be applied to injectable tissue engineering. |
| 저자 |
김지은1, 박지선1, 조용우1, 박근홍2, 송수창1
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| 소속 |
1한국과학기술(연), 2아주대 |
| 키워드 |
injectable; thermosensitive; polyphosphazene; tissue engineering
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| E-Mail |
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