| 초록 |
Both biocompatibility and high adhesion strength of a tissue adhesive are critical for wound closing, hemostasis, and injury healing. To coexist both properties, chitosan was chemically modified by the enzymatic activation of catechol. Catechol containing molecules were oxidized by enzyme and the activated catechol groups were grafted onto a chitosan backbone. To optimize the balance between cohesive and interfacial adhesive forces of modified chitosan, the oxidation of catechol moieties and substitution degree were controlled. The physico-chemical properties and adhesive strength of the modified chitosan were characterized. Our results demonstrate that enzymatic oxidation of catechol and balanced adhesive/cohesive forces would be beneficial to the field of surgical operation as effective tissue-adhesive medical devices. |
