| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effects of a hydrogel-seeding method on cell adhesion and proliferation into PLCL scaffold for vascular tissue engineering |
| 초록 |
Porosity and pore size need to be considered for successful cell seeding and proliferation into porous scaffolds. This study was focused on a hydrogel-seeding method to improve cell adhesion and proliferation in tubular porous scaffolds for vascular grafts application. Tubular scaffolds were fabricated by an extrusion-particulate leaching method using the biodegradable elastic polymer, poly(lactide-co-ε-caprolactone) (PLCL) (50:50, Mn 1.58×105). Vascular smooth muscle cells (VSMCs) were seeded with collagen hydrogel into the tubular PLCL scaffolds having various pore size. As a result, the efficiency of cell adhesion and proliferation was dependent on the pore size of the scaffolds. Especially, the cell proliferation efficiency improved by using the hydrogel-seeding method as compared with by using an established method. |
| 저자 |
박인수, 김상헌, 한정우, 고영건, 정은나, 김수현
|
| 소속 |
한국과학기술(연) |
| 키워드 |
vascular tissue engineering; hydrogel-seeding method; collage
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| E-Mail |
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