| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
학생우수논문발표(박사과정) |
| 제목 |
Design of multifunctional nanoparticle-based drug delivery system (NDDS): poly(acrylic acid)-calcium phosphate (PAA-CaP) passivated TiO2 nanoparticles for pH-responsive drug release and photodynamic therapy (PDT) capabilities |
| 초록 |
One of the major challenges for cancer therapy using nanoparticle-based drug delivery system (NDDS) is selective toxicity for tumor cells. The strategy of designing and developing multifunctional NDDS has to be explored to overcome the limits of the treatments. Herein, we successfully synthesized poly(acrylic acid)-calcium phosphate (PAA-CaP) passivated TiO2 nanoparticles (TiO2@PAA-CaP NPs) equipped with dual functional capabilities such as pH-responsive drug release and photodynamic therapy (PDT). TiO2@PAA-CaP NPs exhibited higher drug loading capacity and pH-selective release. In-vitro tests revealed that drug-loaded TiO2@PAA-CaP NPs exhibited efficient cytotoxicity, likely followed by enhanced cellular uptake. Furthermore, drug-loaded TiO2@PAA-CaP NPs under UV irradiation exhibited overall higher cytotoxicity likely due to synergistic effects of efficient NDDS and enhanced PDT characteristics. |
| 저자 |
한지훈1, 기미란2, 장의경2, 손려강2, 백승필2, 정성욱1
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| 소속 |
1부산대, 2고려대 |
| 키워드 |
nanoparticle-based drug delivery system (NDDS); photodynamic therapy(PDT)
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| E-Mail |
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