| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
IR-780 dye loaded Zwitterionic Micellar Nanoparticle for NIR imaging and Photothermal therapy in a Cervical tumor model. |
| 초록 |
PEGylation of nanoparticles supports in long term circulation of nanoparticle in blood stream, although it limits the intracellular uptake of nanoparticle. Hence, we developed a micellar nanoparticles using the amphiphilic zwitterionic polymer-lipid synthesized via RAFT polymerization, and encapsulated with IR-780 dye (PCB-lipid–IR-780). The nanoparticle exhibited low cytotoxicity and remarkable photothermal cytotoxicity to cervical cancer cells (TC-1) upon near-infrared (NIR) laser irradiation. The PCB-lipid–IR-780 nanoparticle showed higher accumulation in tumor and following NIR laser irradiation of the tumor region resulted in enhanced tumor ablation and subsequent tumor regression in the TC-1 xenograft model. Hence, these zwitterionic polymer-lipid hybrid micellar nanoparticles show great potential for cancer theranostics and might be beneficial for clinical applications. |
| 저자 |
ADITYANARAYAN MOHAPATRA, Rajendrakumar Santhosh Kalash, Shameer Pillarisetti, 박인규
|
| 소속 |
Chonnam National Univ. |
| 키워드 |
Theranostic; zwitterionic; Near-infrared; photothermal; cervical cancer
|
| E-Mail |
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